Professor David E. James
is the Leonard P. Ullman Chair of Metabolic Systems Biology at the Charles Perkins Centre and Professor in the School of Molecular Bioscience and the Sydney Medical School at the University of Sydney. David undertook his PhD at the Garvan Institute of Medical Research and his undergraduate degree and Honors at University of New South Wales.
David has made major contributions to our understanding of insulin action. In the late 1980s he published a series of journal articles in Nature describing the identification and characterization of the insulin responsive glucose transporter GLUT4. He then focused his efforts on unveiling the cellular and molecular control of insulin-stimulated glucose transport. He has also made contributions in the area of SNARE proteins, signal transduction and more recently in systems biology.
His group at the Cellular Systems Biology lab studies changes in system behavior during key transition states, particularly those involving altered nutrition. Part of his research involves molecular analysis of insulin action using a range of model systems. A major focus is to dissect the interaction between signal transduction and metabolism with emphasis on the Akt pathway in adipocytes.
« Go Back